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Combined chemotherapy and radiation therapy have been reported to produce a high incidence of complete regression of epithelial cancer of the anal canal, resulting in prolonged disease-free survival. This modality has been advocated as an alternative to abdominoperineal resection as a primary treatment for this disease. Our group treated 19 patients between 1979 and 1985. Treatment included two infusions of 5-fluorouracil (1000 mg/m2/24 hours), one dose of mitomycin C (15 mg/m2), and simultaneous whole-pelvis radiation (3000 rad). The complete response rate was 88%. Three patients had anal cancer incompletely controlled by that therapy. They underwent abdominoperineal resections and are alive without disease at 10, 39, and 43 months, respectively. Actuarial disease-free survival at 40 months was 87.5 +/- 8.8 (% +/- standard error of the mean [SEM]). Complications included gastrointestinal, hematologic, and cutaneous toxicity. These results confirmed a high complete response rate to this therapy. Local treatment failures may occur, but these may be salvaged with abdominoperineal resection.
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
March 1998,
Oncology (Williston Park, N.Y.),
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
December 1992,
International journal of colorectal disease,
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
May 1983,
Cancer,
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
April 2004,
Surgical oncology clinics of North America,
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
April 1993,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
March 1982,
Cancer treatment reports,
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
September 1983,
International journal of radiation oncology, biology, physics,
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
January 1981,
Diseases of the colon and rectum,
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
September 1989,
Diseases of the colon and rectum,
W R Meeker, and
B J Sickle-Santanello, and
G Philpott, and
D Kenady, and
K I Bland, and
G H Hill, and
M B Popp
May 1994,
Radiology,
