-transparent.png){kind=logo}
Cytogenetic analysis of a Ewing's sarcoma revealed a 46,XX,t(8;18)(q11;q21.3), t(11;22)(q23-24;q11-12) chromosome pattern. Observation of t(11;22) is consistent with other reported cases of Ewing's sarcoma. One breakpoint in this translocation, 11q23, coincides with the location of a folate-sensitive fragile site. Examination of peripheral blood leukocyte chromosomes from the patient revealed a 46,XX chromosome pattern with spontaneous, fluorodeoxyuridine-, and Bactrim-induced expression of fra(11)(q23). This may be the first demonstration of constitutional fra(11)(q23) expression in a patient with a neoplasm that exhibits a chromosome rearrangement involving this breakpoint and the first observation of spontaneous expression of this fragile site. These results provide a basis for discussion of the relationship between fragile sites and chromosome rearrangements.
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
January 2021,
Frontiers in medicine,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
May 2000,
Human genetics,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
January 1990,
Japanese journal of medicine,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
July 2010,
European journal of human genetics : EJHG,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
October 2006,
Genes, chromosomes & cancer,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
October 1979,
Human genetics,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
February 1989,
Genome,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
March 2014,
Leukemia & lymphoma,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
December 1986,
Journal of the National Cancer Institute,
S M Gollin, and
L J Perrot, and
B A Gray, and
M Kletzel
September 2019,
International journal of cancer,
