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We measured creatinine in plasma and urine samples from 17 normal subjects and 10 renally impaired subjects by four different methods: two enzymatic--Ektachem iminohydrolase and Boehringer Mannheim amidohydrolase--and two Jaffé reaction based--Beckman Astra 8 and Technicon AutoAnalyzer I. Creatinine clearances, standardized for body surface area, were also calculated. In both groups of subjects plasma creatinine values were significantly (p less than 0.05) lower, by 3 to 4 mg/L, when measured enzymatically than when measured by the Jaffé reaction. Additionally, creatinine clearances were significantly (p less than 0.05) greater by at least 30 mL/min when calculated from enzymatically measured creatinine values vs Jaffé method values for creatinine. The benefits of lack of interference with enzymatically measured creatinine concentrations and clearances should be assessed in relation to the lack of agreement with long-established (Jaffé) methods for determining creatinine (and inulin) clearances.
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
September 1979,
Clinical chemistry,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
July 1996,
Nihon Jinzo Gakkai shi,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
June 2004,
Clinica chimica acta; international journal of clinical chemistry,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
January 2000,
Clinical laboratory,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
September 1985,
Clinical chemistry,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
November 1977,
Scandinavian journal of clinical and laboratory investigation,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
September 1992,
Annals of clinical biochemistry,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
February 1983,
Drug intelligence & clinical pharmacy,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
November 1979,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
F Apple, and
C Bandt, and
A Prosch, and
G Erlandson, and
V Holmstrom, and
J Scholen, and
M Googins
May 1984,
Lancet (London, England),
