Biomaterial Database

Concentrations of free testosterone, total testosterone, and androgen binding protein in the peripheral serum of male rats during sexual maturation. 1986

S J Nazian

To investigate the relationship between free testosterone and sexual maturation in the male rat, animals were decapitated every 5 days from 25 through 75 days of life. Serum was assayed for androgen binding protein and total testosterone by radioimmunoassay. Free testosterone concentrations were calculated from the total testosterone concentration and the free testosterone fraction. The free testosterone fraction was determined by ultrafiltration. The pubertal increase in relative prostate and relative seminal vesicle weights began between 45 and 50 days and 40 and 45 days, respectively. Although the over-all trend in the free testosterone fraction was to increase with increasing age (r = 0.46, P less than 0.0001), there was a significant secondary peak at 50 days. The serum concentration of androgen binding protein was highest on day 25, fell rapidly until day 40, and declined slowly thereafter. Despite these variations in both androgen binding protein and the free testosterone fraction during sexual maturation, the calculated serum concentration of free testosterone was remarkably similar in pattern to that of total testosterone (r = 0.99, P less than 0.0001). These data indicate that the serum concentration of total testosterone is an accurate reflection of the serum concentration of free testosterone during the sexual maturation of the male rat.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011467	Prostate	A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.	Prostates
D000375	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	Senescence,Aging, Biological,Biological Aging
D000727	Androgen-Binding Protein	Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.	Androgen Binding Protein,Binding Protein, Androgen,Protein, Androgen Binding,Protein, Androgen-Binding
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012741	Sexual Maturation	Achievement of full sexual capacity in animals and in humans.	Sex Maturation,Maturation, Sex,Maturation, Sexual
D013737	Testis	The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.	Testicles,Testes,Testicle
D013739	Testosterone	A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.	17-beta-Hydroxy-4-Androsten-3-one,17-beta-Hydroxy-8 alpha-4-Androsten-3-one,8-Isotestosterone,AndroGel,Androderm,Andropatch,Androtop,Histerone,Sterotate,Sustanon,Testim,Testoderm,Testolin,Testopel,Testosterone Sulfate,17 beta Hydroxy 4 Androsten 3 one,17 beta Hydroxy 8 alpha 4 Androsten 3 one,8 Isotestosterone
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus