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Fifteen consecutively identified patients with syndromally defined postpsychotic depression were followed prospectively over three consecutive weekly ratings to assess the stability of that syndrome. In 8 cases, the condition persisted with undiminished intensity. Five cases remitted spontaneously, and in 2 cases the syndrome appeared to be a harbinger of psychotic relapse. The implications for the timing of therapeutic interventions in patients with postpsychotic depressions are discussed.
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