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High-activity iodine-125 sources in plastic catheters were surgically placed in the cerebral white matter of healthy beagle dogs and later removed. Reference doses, calculated at a point 0.75 mm from the source, ranged from 10 to 40 Gy. Necrosis, vascular-related damage, and edema were quantified by computed tomography. Volumetric analyses were used to derive the relationship of dose and dose rate to necrosis and contrast enhancement. The extent of necrosis was related to irradiated volume; a minimum effective dose averaging 180-200 Gy was required to induce this type of damage. Contrast enhancement was less dependent on irradiated volume or total dose. The extent of radiation-induced edema was directly related to the volumes of necrosis plus contrast enhancement. Noninvasive serial studies in a well-characterized in vivo model can address specific clinically related questions on damage to normal tissue after interstitial irradiation.
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
December 2016,
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery,
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
December 1980,
International journal of radiation oncology, biology, physics,
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
April 2000,
Radiation research,
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
May 1987,
Radiation research,
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
September 2017,
Ocular oncology and pathology,
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
January 1987,
Applied neurophysiology,
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
July 1985,
Strahlentherapie,
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
July 1997,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
June 1995,
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al],
K Turowski, and
J R Fike, and
C E Cann, and
R J Higgins, and
R L Davis, and
P H Gutin, and
T L Phillips, and
K A Weaver
March 2010,
International journal of radiation oncology, biology, physics,
