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The potential of unleaded gasoline and 2,2,4-trimethylpentane to induce gene locus mutation and sister-chromatid exchange in human lymphoblasts in vitro was determined. Neither unleaded gasoline, at its maximum tolerated concentration in the medium, nor 2,2,4-trimethylpentane, at its limit of solubility, induced mutation at the thymidine kinase locus. Negative results were seen both in the presence and absence of a rat liver homogenate metabolizing system. Sister-chromatid exchange analyses of the cultures treated with unleaded gasoline and 2,2,4-trimethylpentane were also negative. Therefore the carcinogenicity and nephrotoxicity of unleaded gasoline and 2,2,4-trimethylpentane observed in vivo are not correlated with any marked genotoxicity in these in vitro tests.
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
August 1986,
Toxicology and applied pharmacology,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
December 1989,
Toxicology and applied pharmacology,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
March 1987,
Toxicology and applied pharmacology,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
November 1989,
Cancer research,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
October 1964,
Radiation research,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
October 1987,
Journal of applied toxicology : JAT,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
January 1985,
Mutation research,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
October 1948,
Journal of the American Chemical Society,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
September 1990,
Toxicology letters,
K A Richardson, and
J L Wilmer, and
D Smith-Simpson, and
T R Skopek
May 1975,
Radiation research,
