-transparent.png){kind=logo}
We investigated the effects of ethinyl estradiol (5 mg/kg body wt daily for 5 days, orally) and/or iron sorbitol (50 mg/kg body wt daily for 5 days, i.m.) on bile flow, bile salt independent fraction (BSIF), hepatic delta-aminolevulinate synthase (ALA-S) and uroporphyrinogen decarboxylase (URO-D) in female rats. Ethinyl estradiol administration was associated with a significant decrease of bile flow and BSIF and an increase in URO-D activity in comparison to control values. Iron alone did not modify biliary parameters, but significantly increased the activity of ALA-S. Combined treatment with ethinyl estradiol plus iron partially corrected the reduction of BSIF and restored the activity of ALA-S and URO-D to control levels. Thus iron appears to exert a partially protective effect against ethinyl estradiol-induced cholestasis. No porphyrinogenic effect was observed.
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
November 1989,
Journal of lipid research,
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
January 1986,
Voprosy meditsinskoi khimii,
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
March 1980,
Biochemical pharmacology,
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
January 1990,
Hepatology (Baltimore, Md.),
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
November 1979,
The Journal of biological chemistry,
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
April 1988,
Contraception,
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
December 1982,
Die Medizinische Welt,
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
April 1981,
Journal of pharmaceutical sciences,
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
July 2024,
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS),
L Cantoni, and
C Di Padova, and
M Rizzardini, and
D Dal Fiume, and
A Graziani, and
P Rovagnati, and
R Tritapepe
January 1985,
Hepatology (Baltimore, Md.),
