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Rotation mobility of stearic acid spin labelling in mitochondria and microsomes of 24 months old rats is shown to decrease in comparison with that of 1 month rats. This decrease correlates with an increase in the free cholesterol content in membranes. The phospholipid composition is practically unchanged. With age the osmoresistance of organelles decreases and the cryoresistance increases, supporting indirectly the existence of structural changes in membranes with ageing. The most pronounced activation of NADPH-cytochrome C reductase in the microsomal membrane after the treatment with triton X-100 is observed in case of old animals. The thyroxine treatment of old rats causes a "rejuvenative" effect on the structural state of mitochondrial and microsomal membranes, evidencing for the important role of hormonal regulation in mechanisms of their age rearrangement.
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
January 1986,
Annals of the New York Academy of Sciences,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
December 1989,
Biochemical and biophysical research communications,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
December 1971,
Biochemical and biophysical research communications,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
April 1987,
Biochemical and biophysical research communications,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
December 1993,
Cell structure and function,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
October 1978,
Biochimica et biophysica acta,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
December 1970,
Archives internationales de physiologie et de biochimie,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
December 1970,
Biochimica et biophysica acta,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
March 1973,
The Journal of cell biology,
V V Lemeshko, and
N A Babenko, and
L Ia Popova, and
L I Belostotskaia, and
E V Kozlova
August 1982,
Journal of lipid research,
