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Antibiotics were given intravenously to dogs with chronic pancreatic fistulas, and serum and pancreatic juice levels were measured. Despite adequate serum values, gentamicin, tetracycline, clindamycin, and moxalactam did not appear in the pancreatic juice, which suggested a barrier to their excretion. In contrast, chloramphenicol reached a peak concentration in the pancreatic juice that amounted to 36 percent of the peak serum value. In the pancreatic juice, ampicillin, cefoxitin, and cefamandole reached only 5 percent of the peak serum values but were still within the therapeutic range. We have concluded that there is a blood-pancreatic juice barrier to some antibiotics, which leads to selective excretion.
G P Burns, and
T A Stein, and
L S Kabnick
May 1997,
Zhonghua wai ke za zhi [Chinese journal of surgery],
G P Burns, and
T A Stein, and
L S Kabnick
September 1983,
Vestnik khirurgii imeni I. I. Grekova,
G P Burns, and
T A Stein, and
L S Kabnick
January 1975,
Digestion,
G P Burns, and
T A Stein, and
L S Kabnick
March 1999,
Zhonghua wai ke za zhi [Chinese journal of surgery],
G P Burns, and
T A Stein, and
L S Kabnick
January 1964,
Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie,
G P Burns, and
T A Stein, and
L S Kabnick
April 1990,
Transplantation proceedings,
G P Burns, and
T A Stein, and
L S Kabnick
September 1974,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
G P Burns, and
T A Stein, and
L S Kabnick
May 1961,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G P Burns, and
T A Stein, and
L S Kabnick
April 1970,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
G P Burns, and
T A Stein, and
L S Kabnick
January 1974,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
