The most important methods and results found in literature on immunoglobulins of the normal cerebrospinal fluid (CSF) are reviewed. A study was made of immunoglobulins in the CSF of 50 individuals who suffered from chronic migraine but showed normal results for the physical and neurological examinations; electroencephalograph, CSF tests (sub-occipital puncture) and proteinogram of the serum also fell within the limits of normalcy in all of the 50 cases. The study of immunoglobulins was conducted through the radial immunodifusion method. Results obtained as to immunoglobulins of the CSF varied between 1,55 and 3,97 mg/100 ml, or 0,17 and 0,44 for IGG; values lay between 0 and 0,62 mg/100 ml, or 0,37 UI for IGA. Presence of IGM was not detected in any of the cases studied. Analysis of the results showed that, for the CSF of the cisterna magna in normal individuals, IGG is always found at an average concentration of 2,37 mg/100 ml and a standard deviation of 0,59. IGA is mostly found at an average concentration of 0,34 mg/100 ml and a standard deviation of 0,17. IGM is not demonstrable, under normal conditions, by the method chosen by the author.