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An artificial endocrine pancreas has been developed by adding a glucose infusion system to the artificial beta cell system. In this computer algorithm, glucose is infused on the basis of proportional and derivative actions to blood glucose concentration with the time delay constant between blood withdrawal and initiation of glucose infusion. When glucose was infused on the basis of proportional action with a 20-minute time delay, the prompt restoration to normoglycemia from the hypoglycemic state with a smaller amount of glucose was shown in depancreatized dogs. These results indicate that the artificial endocrine pancreas thus prepared is not only a useful device to safely control blood glucose, but also is an efficient research tool for the analysis of the blood glucose regulatory mechanism.
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
March 1983,
Nihon Naibunpi Gakkai zasshi,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
May 1974,
Diabetes,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
January 2003,
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
May 1977,
Archives of internal medicine,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
September 1985,
Canadian Anaesthetists' Society journal,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
September 2001,
Journal of the American College of Surgeons,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
December 1990,
Nihon rinsho. Japanese journal of clinical medicine,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
March 1979,
Khirurgiia,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
November 1989,
Nihon rinsho. Japanese journal of clinical medicine,
Y Yamasaki, and
M Shichiri, and
R Kawamori, and
Y Goriya, and
T Sasai, and
T Morishima, and
M Nomura, and
R Tohdo, and
H Abe
February 1983,
Journal of endocrinological investigation,
