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The damage of DNA structure and synthesis in murine leukemia L1210 cells upon single administration in therapeutic doses of antitumour agents of N-nitrosourea type, such as 1-methyl-1-nitrosourea (MNU) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was studied. MNU and BCNU were characterized by stronger inhibitory effects on de novo DNA synthesis compared to additional pathway of DNA synthesis in leukemia L1210 cells in vivo. Centrifugation in alkaline sucrose density gradients of L1210 cell lysates has revealed persistent single-strand breaks and alkaline-labile sites in newly replicated DNA. Parental DNA structure was more stable to damaging drug effects than that of newly replicated DNA. The results are consistent with our previous data on the differences in the mechanisms of MNU and BCNU action and the absence of complete cross resistance between the drugs.
E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
July 1984,
Biokhimiia (Moscow, Russia),
E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
January 1988,
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E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
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E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
January 1992,
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E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
July 1977,
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E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
January 1980,
Leukemia research,
E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
January 1980,
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E D Durdyeva, and
G V Kukushkina, and
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May 1967,
Cancer research,
E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
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E D Durdyeva, and
G V Kukushkina, and
K B Gorbacheva
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