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Degenerative and regenerative changes induced in rat liver by single exposure to diethylnitrosamine (DEN) were examined by morphological and biochemical approaches. Apoptotic changes were observed in livers of rats exposed to a 'subnecrogenic' dose of DEN (10 mg/kg) as well as in liver parenchyma of those receiving a necrogenic dose (100 mg/kg). Zonal centrilobular necrosis was observed exclusively in the latter group. Regenerative changes, i.e., increases in DNA synthesis, labeling index and mitotic activity, occurred only in animals exposed to the higher dose. The mitogenic effect obtained in these conditions was about half that induced by two-thirds hepatectomy and the maximum response occurred about 24 h later than in partially hepatectomized rats.
R Daoust, and
R Morais
January 1990,
Roczniki Panstwowego Zakladu Higieny,
R Daoust, and
R Morais
January 1974,
Experimentelle Pathologie,
R Daoust, and
R Morais
January 1992,
Pancreas,
R Daoust, and
R Morais
November 1974,
Biulleten' eksperimental'noi biologii i meditsiny,
R Daoust, and
R Morais
August 1992,
Journal of applied toxicology : JAT,
R Daoust, and
R Morais
December 1973,
Biulleten' eksperimental'noi biologii i meditsiny,
R Daoust, and
R Morais
October 1976,
Tsitologiia,
R Daoust, and
R Morais
November 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R Daoust, and
R Morais
October 1962,
Beitrage zur pathologischen Anatomie und zur allgemeinen Pathologie,
R Daoust, and
R Morais
July 1976,
Experimental cell research,
