Biomaterial Database

An ipsilateral olivocerebellar connection: an autoradiographic study in the unilaterally pedunculotomised neonatal rat. 1986

R M Sherrard, and A J Bower

Using autoradiographic techniques the olivocerebellar pathway was investigated in neonatal rats which had undergone a left cerebellar pedunculotomy on postnatal day 7 (p7). Tritiated (3H) leucine was injected into the right inferior olive at the same time as the pedunculotomy and the animals were allowed to survive for two or four days. Autoradiographs were then made of the brainstem and the cerebellum. Only those animals which had had a total left cerebellar pedunculotomy and in which the 3H-leucine did not spill into the left inferior olive were included in the experiment. The results showed the presence of climbing fibres in the cerebellar hemisphere ipsilateral to the injection site, arranged in sagittal bands and topographically organised. The only route for those fibres to enter the cerebellum is through the inferior cerebellar peduncle ipsilateral to the injected olive which is a pathway not present in the adult animal. The possible explanations for these results are discussed.

UI	MeSH Term	Description	Entries
D009434	Neural Pathways	Neural tracts connecting one part of the nervous system with another.	Neural Interconnections,Interconnection, Neural,Interconnections, Neural,Neural Interconnection,Neural Pathway,Pathway, Neural,Pathways, Neural
D009847	Olivary Nucleus	A brainstem nuclear complex. in the hindbrain, also referred to as the olivary body. The olivary nuclear complex is a part of the MEDULLA OBLONGATA and the PONTINE TEGMENTUM. It is involved with motor control and is a major source of sensory input to the CEREBELLUM.	Basal Nucleus, Olivary,Nucleus Basalis, Olivary,Olivary Body,Olivary Complex,Olivary Nuclei,Complex, Olivary,Nucleus, Olivary,Nucleus, Olivary Basal,Olivary Basal Nucleus,Olivary Bodies
D002531	Cerebellum	The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.	Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000831	Animals, Newborn	Refers to animals in the period of time just after birth.	Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus