-transparent.png){kind=logo}
The possible involvement of phospholipase A2 (PLA2) in the release of catecholamines was examined in a cell-free model system, using isolated chromaffin granules and plasma membranes of adrenal medulla cells. Plasma membranes treated with PLA2 in the presence of Ca2+ caused lysis of chromaffin granules which was also dependent on Ca2+. This finding suggests that Ca2+ acts in two steps of exocytosis, namely in the transformation of plasma membranes into a lytic form by PLA2 and in the interaction of chromaffin granules with plasma membranes. These findings show good agreement with recently reported findings in leaky adrenal medulla cells, and suggest the involvement of PLA2 in the release of catecholamines.
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
October 1987,
Biochemical and biophysical research communications,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
October 1987,
FEBS letters,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
April 1981,
FEBS letters,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
December 1982,
Archives internationales de pharmacodynamie et de therapie,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
January 1998,
International review of cytology,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
January 1983,
Biochemical and biophysical research communications,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
October 2008,
The European journal of neuroscience,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
September 1994,
Annals of the New York Academy of Sciences,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
April 1995,
The Biochemical journal,
F Izumi, and
N Yanagihara, and
A Wada, and
Y Toyohira, and
H Kobayashi
July 1976,
Molecular pharmacology,
