-transparent.png){kind=logo}
The effect of domperidone, a peripheral dopamine receptor antagonist, has been studied in the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats. The gastric anti-ulcer activity of domperidone was evident following a single dose as well as a 5-day pretreatment against all the three ulcerogenic drugs. However, the protection in the five-day pretreatment group was greater than in the single dose pretreatment group. It appears that the gastrokinetic properties of domperidone play a significant role in producing this anti-ulcer effect. The study substantiates the results of the clinical observations on the healing of gastric ulcers and provides a rationale for further clinical studies in that direction. The possible mechanisms of action of this agent are discussed.
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
January 2014,
International journal of clinical and experimental medicine,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
January 2003,
Research communications in molecular pathology and pharmacology,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
September 2009,
Die Pharmazie,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
July 1979,
Canadian journal of surgery. Journal canadien de chirurgie,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
July 2011,
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
April 2013,
Inflammation,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
February 2018,
European journal of pharmacology,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
February 2005,
American journal of physiology. Gastrointestinal and liver physiology,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
July 1993,
American journal of veterinary research,
N S Parmar, and
M Tariq, and
A M Ageel, and
K I Al-Khamis
January 1981,
Arzneimittel-Forschung,
