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Senile macular degeneration (SMD) is a leading cause of registered blindness in the United States and other Western countries. Loss of central vision develops as a result of atrophy of the retinal pigment epithelium or subretinal neovascularisation. The histopathology of the atrophic form of SMD has not been extensively studied. This paper illustrates at the light and electron microscope level the involvement the atrophic form of SMD. Additional features including pigment clumping and detachment of the retinal pigment epithelium at the advancing edge of the lesion are illustrated. Giant cells and MPS cells are typical features of granulomatous inflammation, and results suggest that they may play a role in the pathogenesis of SMD.
P L Penfold, and
M C Killingsworth, and
S H Sarks
August 1978,
The British journal of ophthalmology,
P L Penfold, and
M C Killingsworth, and
S H Sarks
January 1975,
Archives of ophthalmology (Chicago, Ill. : 1960),
P L Penfold, and
M C Killingsworth, and
S H Sarks
January 1983,
Bulletin de la Societe belge d'ophtalmologie,
P L Penfold, and
M C Killingsworth, and
S H Sarks
December 1997,
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft,
P L Penfold, and
M C Killingsworth, and
S H Sarks
January 1987,
Bulletin des societes d'ophtalmologie de France,
P L Penfold, and
M C Killingsworth, and
S H Sarks
July 1998,
Klinische Monatsblatter fur Augenheilkunde,
P L Penfold, and
M C Killingsworth, and
S H Sarks
November 1972,
Archives of ophthalmology (Chicago, Ill. : 1960),
P L Penfold, and
M C Killingsworth, and
S H Sarks
September 2017,
Ophthalmic surgery, lasers & imaging retina,
P L Penfold, and
M C Killingsworth, and
S H Sarks
January 2010,
Oftalmologia (Bucharest, Romania : 1990),
P L Penfold, and
M C Killingsworth, and
S H Sarks
December 2016,
Retina (Philadelphia, Pa.),
