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The responses of guinea pigs and rats to inhaled sulfuric acid aerosols were compared to define species differences and to determine the small-animal model most relevant to human exposures. Rats were exposed for 6 h to 1, 10, and 100 mg H2SO4/m3. Guinea pigs were exposed for 6 h to 1, 10, and 27 mg H2SO4/m3. Tracheal mucous clearance of guinea pigs was slowed 1 d after exposures to 1 mg H2SO4/m3. A tendency toward faster clearance was observed at high concentrations of H2SO4 for both guinea pigs and rats (statistically significant only for the rats). The speeding of mucous clearance was correlated with increases in airway sialic acid and also with the appearance of excess tracheal secretions, detected using scanning electron microscopy in both rats and guinea pigs. The responses of guinea pigs to sulfuric acid exposures were more similar to those reported for humans than were those of rats.
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
April 1952,
A.M.A. archives of industrial hygiene and occupational medicine,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
January 1983,
Journal of toxicology and environmental health,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
November 1958,
A.M.A. archives of industrial health,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
October 1977,
Journal of toxicology and environmental health,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
January 1978,
Journal of toxicology and environmental health,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
January 1978,
Journal of toxicology and environmental health,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
January 1978,
Journal of environmental pathology and toxicology,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
January 1983,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
October 1952,
A.M.A. archives of industrial hygiene and occupational medicine,
R K Wolff, and
R F Henderson, and
R H Gray, and
R L Carpenter, and
F F Hahn
July 1973,
Archives of environmental health,
