A morphometric study of vein graft intimal hyperplasia. 1986

R J Dilley, and J K McGeachie, and F J Prendergast

The extent of intimal hyperplasia in veins grafted into arteries is a major determinant of graft survival. The development of intimal hyperplasia in experimental iliolumbar vein grafts in iliac arteries of 36 rats was followed by light microscopy between 2 and 140 days after grafting. The increase in mean thickness of the graft intima was most rapid from 2 to 21 days and then more gradual to reach a maximum at 140 days, when the graft intima was the same thickness as the combined intima and media of the control artery. Grafts aged between 15 and 28 days showed a significant thickening at the anastomosis, but this was not evident in older grafts. Our results quantitate the arterialization of a vein graft and show that there is no significant anastomotic intimal hyperplasia in mature grafts in this model.

UI MeSH Term Description Entries
D006965 Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells. Hyperplasias
D007083 Iliac Artery Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs. Deep Circumflex Iliac Artery,Arteries, Iliac,Artery, Iliac,Iliac Arteries
D007084 Iliac Vein A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava. Deep Circumflex Iliac Vein,Iliac Veins,Vein, Iliac,Veins, Iliac
D008161 Lumbosacral Region Region of the back including the LUMBAR VERTEBRAE, SACRUM, and nearby structures. Lumbar Region,Lumbar Regions,Lumbosacral Regions,Region, Lumbar,Region, Lumbosacral,Regions, Lumbar,Regions, Lumbosacral
D008297 Male Males
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D006085 Graft Survival The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host. Graft Survivals,Survival, Graft,Survivals, Graft
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001158 Arteries The vessels carrying blood away from the heart. Artery
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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