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Ninety-two patients with advanced non-small cell lung cancer were treated with a combination chemotherapy regimen containing cisplatin, vindesine, and etoposide. Eighteen patients (20%) achieved major responses to therapy (three complete responders and 15 partial responders). Response rates were similar in each histologic subtype. Initial performance status was an important determinant of response; 42% of the patients with a Karnofsky performance status greater than or equal to 70% responded versus 5% of those with a performance status less than 50%. The median duration of partial response was 21 weeks; complete responders had a median response duration of 50 weeks. The median survival for the entire group was 23.5 weeks. Toxicity with this regimen was acceptable; myelosuppression was the major toxic effect and was severe in only 10% of the patients. This regimen produced response rates comparable to those reported with other combinations containing cisplatin. Survival advantage in patients receiving this treatment is not established.
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
January 1988,
Onkologie,
J D Hainsworth, and
L L Porter, and
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R Birch, and
G Enas, and
F A Greco
May 1990,
Gan to kagaku ryoho. Cancer & chemotherapy,
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
January 1983,
Cancer treatment reports,
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
April 1991,
Gan to kagaku ryoho. Cancer & chemotherapy,
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
February 1982,
Cancer treatment reports,
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
November 1985,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
March 1983,
Cancer,
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
January 1990,
Cancer chemotherapy and pharmacology,
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
June 1991,
Gan to kagaku ryoho. Cancer & chemotherapy,
J D Hainsworth, and
L L Porter, and
D H Johnson, and
K R Hande, and
S N Wolff, and
R Birch, and
G Enas, and
F A Greco
August 1984,
European journal of cancer & clinical oncology,
