Biomaterial Database

Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex. 1986

D P Frush, and J O McNamara

We studied the occurrence of wet dog shakes during the evolution of kindling induced by electrical stimulation of the lateral entorhinal cortex. Wet dog shakes occur with high incidence, particularly early in development of kindling. We also demonstrated that microinjection of colchicine into the hippocampus, but not into neocortex, produced a 95% suppression of wet dog shakes. We propose that the suppressive effect of colchicine is mediated by destruction of dentate granule cells. Together with evidence from other investigations, these data support the idea that activation of hippocampal neurons is essential for production of wet dog shakes induced by stimulation of the limbic system.

UI	MeSH Term	Description	Entries
D007696	Kindling, Neurologic	The repeated weak excitation of brain structures, that progressively increases sensitivity to the same stimulation. Over time, this can lower the threshold required to trigger seizures.	Kindlings, Neurologic,Neurologic Kindling,Neurologic Kindlings
D008032	Limbic System	A set of forebrain structures common to all mammals that is defined functionally and anatomically. It is implicated in the higher integration of visceral, olfactory, and somatic information as well as homeostatic responses including fundamental survival behaviors (feeding, mating, emotion). For most authors, it includes the AMYGDALA; EPITHALAMUS; GYRUS CINGULI; hippocampal formation (see HIPPOCAMPUS); HYPOTHALAMUS; PARAHIPPOCAMPAL GYRUS; SEPTAL NUCLEI; anterior nuclear group of thalamus, and portions of the basal ganglia. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p744; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (September 2, 1998)).	Limbic Systems,System, Limbic,Systems, Limbic
D008297	Male		Males
D002529	Cerebellar Nuclei	Four clusters of neurons located deep within the WHITE MATTER of the CEREBELLUM, which are the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.	Dentate Nucleus,Nucleus Dentatus,Nucleus Emboliformis,Nucleus Fastigii,Nucleus Globosus,Amiculum of the Dentate Nucleus,Anterior Interposed Nucleus,Anterior Interpositus Nucleus,Central Nuclei,Deep Cerebellar Nuclei,Dentate Cerebellar Nucleus,Fastigial Cerebellar Nucleus,Fastigial Nucleus,Intracerebellar Nuclei,Lateral Cerebellar Nucleus,Medial Cerebellar Nucleus,Central Nucleus,Cerebellar Nuclei, Deep,Cerebellar Nucleus,Cerebellar Nucleus, Deep,Cerebellar Nucleus, Dentate,Cerebellar Nucleus, Fastigial,Cerebellar Nucleus, Lateral,Cerebellar Nucleus, Medial,Deep Cerebellar Nucleus,Emboliformis, Nucleus,Fastigii, Nucleus,Globosus, Nucleus,Interposed Nucleus, Anterior,Interpositus Nucleus, Anterior,Intracerebellar Nucleus,Nuclei, Central,Nuclei, Cerebellar,Nuclei, Deep Cerebellar,Nuclei, Intracerebellar,Nucleus Fastigius,Nucleus, Anterior Interposed,Nucleus, Anterior Interpositus,Nucleus, Central,Nucleus, Cerebellar,Nucleus, Deep Cerebellar,Nucleus, Dentate,Nucleus, Dentate Cerebellar,Nucleus, Fastigial,Nucleus, Fastigial Cerebellar,Nucleus, Intracerebellar,Nucleus, Lateral Cerebellar,Nucleus, Medial Cerebellar
D003078	Colchicine	A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).	Colchicine, (+-)-Isomer,Colchicine, (R)-Isomer
D006624	Hippocampus	A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.	Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001522	Behavior, Animal	The observable response an animal makes to any situation.	Autotomy Animal,Animal Behavior,Animal Behaviors
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus