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Using a 0.075% 8-methoxypsoralen solution, minimal phototoxic doses and improvement of psoriasis lesions were investigated in 15 patients suffering from chronic stationary psoriasis. The time interval between topical 8-methoxypsoralen application and long-wave ultraviolet light irradiation was increased stepwise. The mean minimal phototoxic dose declined with increasing time interval and reached its minimum 2 h after 8-methoxypsoralen application. In spite of that, antipsoriatic efficiency was maximal 15 min after application. In order to obtain a favorable relationship between antipsoriatic efficiency and unwanted side effects when using topical PUVA treatment, irradiation should be started 15 min after 8-methoxypsoralen application.
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
June 1997,
The British journal of dermatology,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
May 1994,
The British journal of dermatology,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
February 1987,
Journal of the American Academy of Dermatology,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
June 1991,
Journal of the American Academy of Dermatology,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
June 1991,
Dermatology nursing,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
November 1990,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
April 1993,
Journal of the American Academy of Dermatology,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
May 1998,
The Journal of dermatology,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
January 1990,
The Journal of investigative dermatology,
H Meffert, and
E Rowe, and
M Miehe, and
N Sönnichsen
January 2013,
Advances in clinical and experimental medicine : official organ Wroclaw Medical University,
