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Plasma for fibronectin determinations was obtained from 39 neonates with uncomplicated respiratory distress syndrome (RDS) and from 15 infants with RDS who developed bronchopulmonary dysplasia (BPD). Tracheal lavage fibronectin and albumin concentrations were measured in 15 infants with RDS and 15 with BPD. Control plasma fibronectin values were obtained from 20 healthy preterm infants on days 1, 2, 3, 14, and 30 of life. Control tracheal lavage fibronectin and albumin concentrations were measured in 17 neonates of various gestational ages who required tracheal intubation for nonpulmonary indications. Mean plasma fibronectin concentrations from patients with RDS was 121 +/- 11 micrograms/ml on days 1, 2, and 3, versus control level of 163 +/- 12 micrograms/ml (P less than 0.01). Mean tracheal lavage fibronectin/albumin ratio was 3.8 +/- 0.6 ng per microgram of albumin on days 1 to 5 for infants with RDS, versus control level of 5.6 +/- 3.6 (P = NS). Tracheal lavage fibronectin/albumin ratio from patients with BPD was elevated at 16.3 +/- 5.0 ng fibronectin per microgram of albumin on days 14 to 21, and 23.6 +/- 7.4 on day 30 (P less than 0.05 versus control and and versus RDS days 1 to 10). Low plasma fibronectin concentrations early in RDS may contribute to the development of pulmonary capillary leak. High tracheal lavage fibronectin levels may foster the development of pulmonary fibrosis in patients with BPD.
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
June 1992,
Seminars in perinatology,
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
June 1981,
The Journal of pediatrics,
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
April 1992,
The Journal of pediatrics,
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
February 1996,
Pediatric research,
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
March 1986,
Pediatrics,
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
May 1983,
Chest,
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
March 1992,
Clinics in perinatology,
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
January 2023,
Pediatrics international : official journal of the Japan Pediatric Society,
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
January 1983,
Presse medicale (Paris, France : 1983),
J S Gerdes, and
M C Yoder, and
S D Douglas, and
M Paul, and
M C Harris, and
R A Polin
February 2004,
Pediatric pulmonology,
