Biomaterial Database

In vivo hyperglycemic effect of (-)- and (+)-epinephrine in dogs. 1986

C R Kowarski, and M Y Liaou, and A A Kowarski

(-)-Epinephrine is a major component in the regulation of the physiological homeostasis of glucose levels in the blood. (+)-Epinephrine, a synthetic stereoisomer, has been reported to have 10% of the in vitro adrenergic-lipolytic activity of (-)-epinephrine and only 7% in vitro competitive binding activity to fat cells. The in vivo hyperglycemic effects of the two stereoisomers were studied in 6 dogs using a continuous glucose monitor. The method allowed a direct comparison between the hyperglycemic effects of the two stereoisomers in each dog in the course of each test; therefore, the effect of individual variability of response was eliminated. Previous reports on the relative activity of the two stereoisomers were carried out only in vitro. The previous methods required interassay comparison. The present method is in vivo and uses intra-assay comparison. The hyperglycemic activity of (+)-epinephrine bitartrate was found to have 12.8% of the hyperglycemic activity of its natural (-)-stereoisomer.

UI	MeSH Term	Description	Entries
D001786	Blood Glucose	Glucose in blood.	Blood Sugar,Glucose, Blood,Sugar, Blood
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D004837	Epinephrine	The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.	Adrenaline,4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol,Adrenaline Acid Tartrate,Adrenaline Bitartrate,Adrenaline Hydrochloride,Epifrin,Epinephrine Acetate,Epinephrine Bitartrate,Epinephrine Hydrochloride,Epinephrine Hydrogen Tartrate,Epitrate,Lyophrin,Medihaler-Epi,Acetate, Epinephrine
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013237	Stereoisomerism	The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)	Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer