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Hematologic abnormalities were defined in 31 rhesus monkeys (Macaca mulatta) with simian acquired immune deficiency syndrome (SAIDS). Animals manifested anemia (hypochromic/microcytic), severe neutropenia and progressive lymphopenia, monocytosis and occasional thrombocytopenia. Bone marrow studies showed erythroid hyperplasia with a marked left shift and adequate megakaryocytes. Two animals showed profound hypoplasia of all hematopoietic elements. Most animals were iron deficient, but the course of the anemia suggested additional factors. There was no evidence of immune hemolysis. The pathogenesis of these abnormalities is not clear and will require further study. This reproducible disease will allow studies to elucidate the mechanisms of viral-induced hematologic abnormalities.
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
August 1984,
The American journal of medicine,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
November 1984,
The American journal of cardiology,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
May 1985,
Journal of the National Medical Association,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
June 1987,
Gastroenterology,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
November 1985,
Veterinary immunology and immunopathology,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
June 2011,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
February 1985,
Veterinary immunology and immunopathology,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
February 1984,
The Urologic clinics of North America,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
January 1984,
Nursing times,
M MacKenzie, and
L Lowenstine, and
R Lalchandani, and
N Lerche, and
K Osborn, and
A Spinner, and
M Bleviss, and
R Hendrickson, and
M Gardner
February 1984,
British medical journal (Clinical research ed.),
