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We prospectively studied 14 patients with acute cerebral infarctions using serial 133Xenon inhalation cerebral determination (133Xe-rCBF), scored neurological examinations, and neuropsychological testing. All patients underwent the same battery of tests at 3 days, 1 week, 2 weeks, and 4 weeks after cerebral infarction to determine the prognostic value of early rCBF studies and the chronological relationship of changes in rCBF to clinical status. Baseline rCBF within 3 days of symptoms of acute stroke did not correlate with clinical neurological outcome (r = -0.17, p less than 0.30; r = -0.18, p less than 0.28, for the two indices of rCBF used). Among the 11 patients demonstrating neurological recovery, 7 improved at 1 week, significantly before increases in rCBF (p less than 0.05). We conclude that early baseline rCBF does not predict clinical outcome in patients with acute cerebral infarctions and that return of neurological function precedes rather than follows increases in rCBF.
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J Jaggi, and
M Rosen, and
M Reivich
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Psychological medicine,
A M Burke, and
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H Goldberg, and
T Graham, and
M Kushner, and
W Obrist, and
J Jaggi, and
M Rosen, and
M Reivich
March 2001,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
A M Burke, and
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J Jaggi, and
M Rosen, and
M Reivich
September 2006,
Stroke,
A M Burke, and
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J Jaggi, and
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Neuroimaging clinics of North America,
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January 1992,
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January 1977,
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January 1981,
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