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Second-set Lumbricus terrestris allografts from the same donor to the same recipient undergo accelerated rejection if transplanted less than 10 days after first-set allografts. In contrast, second-set allografts, transplanted at longer intervals (20-90 days) show no accelerated rejection. Accelerated rejection of allotransplants under these kinetic conditions agrees with earlier intrafamilial xenotransplant results obtained in earthworms affirming an essential experimental variable: the time of second-set transplantation. Accelerated rejection, weak specificity, and short-term "memory" are three characteristics of the earthworm's allogeneic cellular defense/immune system. These reactions probably result from intense responses (although of short duration) of coelomocytes activated by first transplants that are still present at the time of second-set grafting but absent or inactive at later periods.
E L Cooper, and
P Roch
February 1965,
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E L Cooper, and
P Roch
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E L Cooper, and
P Roch
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E L Cooper, and
P Roch
August 1968,
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E L Cooper, and
P Roch
July 1992,
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E L Cooper, and
P Roch
January 1993,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
E L Cooper, and
P Roch
April 1975,
Comparative biochemistry and physiology. B, Comparative biochemistry,
E L Cooper, and
P Roch
December 1963,
Science (New York, N.Y.),
E L Cooper, and
P Roch
January 1992,
Tissue & cell,
