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Lead concentrations (microgram/g wet weight) in human bone (tibia) were measured noninvasively in vivo employing an X-ray fluorescence technique. Forty-five workers who had been subjected to chronic industrial exposure were found to have a mean bone lead content of 52.9 micrograms/g wet weight (0 to 198 micrograms/g). In addition to bone lead content, blood lead, body burden of lead as assessed by urinary lead excretion after EDTA chelation, zinc protoporphyrin, and unstimulated urinary lead excretion were evaluated. The results suggest that the in vivo measurement of tibia lead content may serve as an acceptable indicator of body lead burden and provide a practical technique for lead screening purposes. The correlation coefficient between X-ray fluorescence findings and lead excretion following Ca-EDTA administration is 0.69; p less than 0.001.
L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
March 1988,
British journal of industrial medicine,
L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
January 1990,
Basic life sciences,
L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
January 2000,
Physics in medicine and biology,
L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
October 1967,
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L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
August 1987,
Biological trace element research,
L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
March 1978,
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L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
September 1989,
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L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
January 1993,
Basic life sciences,
L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
January 1993,
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L Wielopolski, and
K J Ellis, and
A N Vaswani, and
S H Cohn, and
A Greenberg, and
J B Puschett, and
D K Parkinson, and
D E Fetterolf, and
P J Landrigan
September 1992,
British journal of industrial medicine,
