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Flurbiprofen (Ansaid, Upjohn), a potent new analgesic and anti-inflammatory agent, was compared with phenylbutazone in 90 patients with ankylosing spondylitis. In this double-blind, randomized, 26-week study, a total daily dose of 200 mg of flurbiprofen, administered three times daily, was as effective as 300 mg of phenylbutazone in controlling the pain and other symptoms of ankylosing spondylitis. In some patients, symptoms were adequately controlled by 150 mg of flurbiprofen per day, administered twice daily. There were no statistically significant differences between flurbiprofen and phenylbutazone in the investigators' and patients' assessments of improvement at all key follow-up periods. In addition, there were no consistently significant differences between drugs in the efficacy pain scales and quantitative measurements studied. Flurbiprofen was well tolerated in doses of up to 300 mg per day, and no clinically significant laboratory abnormalities were detected. Flurbiprofen appears to be an excellent alternative to phenylbutazone in the management of patients with ankylosing spondylitis.
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
April 1977,
European journal of clinical pharmacology,
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
October 1980,
The New Zealand medical journal,
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
July 1959,
Rheumatism,
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
June 1986,
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P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
November 1974,
British medical journal,
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
January 1977,
Current medical research and opinion,
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
November 1954,
La Presse medicale,
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
August 1977,
Southern medical journal,
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
March 1974,
Annals of the rheumatic diseases,
P L Lomen, and
L F Turner, and
K R Lamborn, and
E L Brinn, and
L P Sattler
January 1976,
Rheumatology and rehabilitation,
