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Acute pain in the lower extremity, which has previously been attributed to synovitis or fasciitis, develops in about 15 percent of osteoporotic patients treated with sodium fluoride. This report describes 11 osteoporotic women in whom this syndrome developed while they were being treated with sodium fluoride (mean dose 78 mg per day; range, 60 to 90). [99mTc]Hydroxymethylene diphosphonate scintiscanning showed an increased number of foci of abnormal uptake in the lower extremities (p less than 0.05), when compared with results of scintiscanning in 12 nonsymptomatic osteoporotic women treated with sodium fluoride and 12 osteoporotic women treated with oral calcium carbonate only. The increased uptake was not restricted to the areas of pain. Roentgenography revealed stress microfractures in five of the 11 symptomatic patients. It is concluded that the acute lower extremity pain syndrome during fluoride therapy usually results from intense regional bone remodeling, which may be complicated by stress microfractures.
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
March 1990,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
April 1989,
Presse medicale (Paris, France : 1983),
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
January 1989,
Presse medicale (Paris, France : 1983),
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
January 1996,
The Journal of clinical endocrinology and metabolism,
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
February 2017,
Pain management nursing : official journal of the American Society of Pain Management Nurses,
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
March 1984,
Helvetica chirurgica acta,
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
January 2020,
Nursing research,
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
November 2005,
The Journal of the American Academy of Orthopaedic Surgeons,
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
March 1990,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
J D O'Duffy, and
H W Wahner, and
W M O'Fallon, and
K A Johnson, and
J M Muhs, and
J W Beabout, and
S F Hodgson, and
B L Riggs
January 1951,
Marseille chirurgical,
