-transparent.png){kind=logo}
Type D retrovirus was isolated from rhesus macaques with simian acquired immunodeficiency syndrome (SAIDS) and transmitted to healthy rhesus macaques with tissue culture medium containing the virus. The clinical, immunologic, and lymph node morphologic changes were observed in 9 rhesus macaques for 52 weeks after inoculation. A spectrum of clinical signs developed including early death, persistent SAIDS, and apparent remission. Animals that died or developed persistent SAIDS had characteristic lymphoid depletion, persistently depressed peripheral blood mononuclear cell (PBMC) mitogenic response, and decreased serum immunoglobulins. The SAIDS retrovirus (SRV) was recovered from PBMC of 8 of the animals after inoculation. Virus could not be recovered from PBMC of one animal in remission, but this animal developed serum-neutralizing antibodies to SRV after inoculation. Seven of the animals seroconverted to SRV after inoculation, all 9 were seronegative for human T-lymphotropic virus-III, and 5 animals tested were seronegative to human T-lymphotropic virus-I. These findings support the etiologic role of the type D retrovirus in SAIDS and further define the pathogenesis of this disease.
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
January 1990,
Journal of medical primatology,
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
January 1988,
Oral surgery, oral medicine, and oral pathology,
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
January 1993,
Journal of medical primatology,
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
June 1992,
Journal of virology,
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
March 1986,
Science (New York, N.Y.),
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
January 1990,
Journal of medical primatology,
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
February 1984,
Lancet (London, England),
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
January 1989,
Journal of medical primatology,
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
August 1991,
Molecular immunology,
D H Maul, and
N W Lerche, and
K G Osborn, and
P A Marx, and
C Zaiss, and
A Spinner, and
J D Kluge, and
M R MacKenzie, and
L J Lowenstine, and
M L Bryant
September 1989,
Proceedings of the National Academy of Sciences of the United States of America,
