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Twelve patients with cervical intraepithelial neoplasia (CIN) were studied by colposcopy and cervical smears to elucidate the local response to interferon alpha and beta given by perilesional injections and to assess long-term disease remission. In all patients, local inflammatory response was seen and persisted throughout the treatment period. Selective toxic effect was evident by exfoliation of increasing proportion of degenerate to viable dyskaryotic cells, while the normal epithelial cells appeared unaffected, and by the progressive regression of the lesion. Interferon alpha induced complete remission in six of seven (85.7%) patients but three had recurrence 12 to 24 months later, while interferon beta induced complete remission in only two of five (40%) patients.
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W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
August 1990,
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Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
July 1990,
British journal of obstetrics and gynaecology,
Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
April 1990,
Gynecologic oncology,
Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
January 1985,
Acta cytologica,
Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
April 1993,
Obstetrical & gynecological survey,
Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
December 2009,
Cancer immunology, immunotherapy : CII,
Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
January 1995,
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Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
December 1985,
The Nebraska medical journal,
Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
July 1988,
BMJ (Clinical research ed.),
Y C Choo, and
W H Seto, and
C Hsu, and
T C Merigan, and
Y H Tan, and
H K Ma, and
M H Ng
January 1973,
Pathology annual,
