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Vitamin A therapy has been claimed in isolated reports to be of benefit to patients with Crohn's disease. To investigate this further, 86 patients were entered into a long-term double-blind study of vitamin A, 50,000 U twice daily, as compared with placebo. After a mean of 14.1 mo of treatment there was no significant difference between the groups as measured by a variety of activity indices (including the National Cooperative Crohn's Disease Activity Index), the number of acute attacks, and the surgical rate. No toxic effects of vitamin A were observed during the study. In this study vitamin A has not been shown to be of benefit to patients with Crohn's disease who are in remission.
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A Parfitt, and
I N Marks, and
D G Burns, and
M Sherman, and
N Tigler-Wybrandi, and
S Isaacs
January 1987,
Digestion,
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January 1985,
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July 1989,
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January 1995,
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January 1984,
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June 1980,
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A Parfitt, and
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D G Burns, and
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S Isaacs
April 1980,
Lancet (London, England),
J P Wright, and
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A Parfitt, and
I N Marks, and
D G Burns, and
M Sherman, and
N Tigler-Wybrandi, and
S Isaacs
December 1982,
Gastroenterology,
J P Wright, and
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A Parfitt, and
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D G Burns, and
M Sherman, and
N Tigler-Wybrandi, and
S Isaacs
September 1983,
Gastroenterology,
J P Wright, and
A S Mee, and
A Parfitt, and
I N Marks, and
D G Burns, and
M Sherman, and
N Tigler-Wybrandi, and
S Isaacs
January 2019,
Intestinal research,
