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One hundred and four children were initially assessed by clinical, radiological, and endoscopic criteria as chronic inflammatory bowel disease. All were assessed independently using precise histological diagnostic criteria. Fifty eight patients were diagnosed as Crohn's disease, 25 as ulcerative colitis, 15 remained provisionally categorised as indeterminate colitis and six proved to be normal. Diagnostic granulomas were found in 36% of endoscopic biopsies from the 58 children with Crohn's disease. This appears to be an underestimate as only four of 14 children with granulomatous Crohn's disease operated on had granulomas on endoscopic biopsy. This study shows that there is a spectrum of histological appearances in endoscopic biopsies in chronic inflammatory bowel disease in childhood ranging from definite Crohn's disease to definite ulcerative colitis with indeterminate features in between. Accurate histological diagnosis of chronic inflammatory bowel disease is dependent upon either multiple endoscopic biopsies or assessment of a surgically resected specimen.
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
December 1993,
Pediatrics in review,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
December 1983,
Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
March 1994,
Bailliere's clinical gastroenterology,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
March 1994,
Bailliere's clinical gastroenterology,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
March 1994,
Bailliere's clinical gastroenterology,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
January 1999,
Nestle Nutrition workshop series. Clinical & performance programme,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
January 2021,
Journal of digestive diseases,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
January 1998,
Acta medica Austriaca,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
January 1982,
La Pediatria medica e chirurgica : Medical and surgical pediatrics,
S K Chong, and
A J Blackshaw, and
S Boyle, and
C B Williams, and
J A Walker-Smith
February 1984,
Gut,
