-transparent.png){kind=logo}
The effect of changes in sodium and osmolarity on renin secretion has been studied in the isolated perfused rat kidney. Perfusion with low sodium buffer (110 mM/l) produced a significant increase in renin secretion compared with control experiments (Na+:135 mM/l). Since the presence of tubules seems necessary for such an effect to take place, it suggests that the high renin secretion stimulated by a low sodium buffer centers in the Macula densa. Perfusion with high sodium buffer (170 mM/l; osmolarity 350 mOs/l) induces a stimulation on renin release. However, a greater rise in renin is achieved in control experiments if choline chloride increases the osmolarity from 300 to 350 mOs/l. All this suggests that high sodium buffer, independently of its osmotic effect, has an inhibitory role on renin release.
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
November 1968,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
August 1982,
The Journal of pharmacology and experimental therapeutics,
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
April 2006,
American journal of physiology. Renal physiology,
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
November 1984,
Research communications in chemical pathology and pharmacology,
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
October 1968,
Die Medizinische Welt,
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
January 1968,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
November 1973,
Kardiologiia,
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
April 1983,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
October 1996,
British journal of pharmacology,
F Alba, and
C García del Río, and
D Acuña, and
A Soler, and
L García, and
T Quesada
January 1968,
The American journal of physiology,
