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This study compares changes in the livers of rats treated with di(2-ethylhexyl) phthalate (DEHP) and its straight-chain analogs di(n-hexyl) phthalate (DnHP) and di(n-octyl phthalate (DnOP). Groups of rats were fed diets containing 20,000 ppm of one of these compounds. Subgroups were killed after 3, 10, and 21 days, and the livers were examined by histological, cytological, and biochemical methods. The results show considerable differences between the effects of the branched-chain phthalate ester DEHP and its straight-chain analogs. The major effects on the liver following administration of diets containing DEHP were midzonal and periportal accumulation of small droplets of lipid, hepatomegaly accompanied by an initial burst of mitosis, proliferation of hepatic peroxisomes and of smooth endoplasmic reticulum accompanied by induction of peroxisomal fatty acid oxidation, damage to the peroxisomal membranes as evidenced by increased leakage of catalase to the cytosol, and centrilobular loss of glycogen and falls in glucose-6-phosphatase activity and in low-molecular-weight reducing agents. In contrast, diets containing DnHP or DnOP induced accumulation of large droplets of fat around central veins leading, by 10 days, to mild centrilobular necrosis and a very slight induction of one peroxisomal enzyme and an increase in liver weight, but no significant changes in any other parameters which were affected by DEHP.
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
February 1997,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
October 1977,
Food and cosmetics toxicology,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
March 2013,
Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
March 1984,
Acta pharmacologica et toxicologica,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
June 1980,
Environmental research,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
June 2005,
Toxicology,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
March 2007,
Journal of toxicology and environmental health. Part A,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
October 2005,
Bulletin of environmental contamination and toxicology,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
April 2001,
Toxicology letters,
A H Mann, and
S C Price, and
F E Mitchell, and
P Grasso, and
R H Hinton, and
J W Bridges
March 2007,
Asian journal of andrology,
