Pirenzepine and carbenozolone in gastric ulcer. Preliminary results of a multicentre double-blind controlled clinical trial. 1979

L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin

Pirenzepine (PRZ) 75 mg/day for 1 week followed by 50 mg/day for 3 weeks did not show a good activity in gastric ulcer healing in comparison to carbenoxolone (CB) (300 mg/day for 1 week followed by 200 mg/day for 3 weeks). The tolerability of PRZ seemed to be better than that of CB. The increase in the daily dose of PRZ to 100 mg/day for 4 weeks led to better results in the patients who have completed satisfactorily the treatment up to now. PRZ's tolerability was greater than CB's. The results of this study are preliminary to further trial.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010879 Piperazines Compounds that are derived from PIPERAZINE.
D010890 Pirenzepine An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients. Gastrotsepin,Gastrozepin,L-S 519,LS-519,Piren-Basan,Pirenzepin,Pirenzepin Von Ct,Pirenzepin-Ratiopharm,Pirenzepine Dihydrochloride,Pyrenzepine,Ulcoprotect,Ulgescum,Dihydrochloride, Pirenzepine,LS 519,LS519,Piren Basan,Pirenzepin Ratiopharm,Von Ct, Pirenzepin
D002229 Carbenoxolone An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. Carbenoxalone,18alpha-Carbenoxolone,18alpha-Glycyrrhetinic Acid 3beta-O-Hemisuccinate,Biogastrone,Bioral,Carbeneoxolone,Carbenoxolone Disodium Salt,Carbenoxolone Sodium,Carbosan,Duogastrone,Glycyrrhetinic Acid 3-O-hemisuccinate,Pharmaxolon,Sanodin,18alpha Carbenoxolone,18alpha Glycyrrhetinic Acid 3beta O Hemisuccinate,3-O-hemisuccinate, Glycyrrhetinic Acid,3beta-O-Hemisuccinate, 18alpha-Glycyrrhetinic Acid,Acid 3-O-hemisuccinate, Glycyrrhetinic,Acid 3beta-O-Hemisuccinate, 18alpha-Glycyrrhetinic,Glycyrrhetinic Acid 3 O hemisuccinate
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females
D006034 Glycyrrhetinic Acid An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. Enoxolone,Glycyrrhetic Acid,Rhetinic Acid,Uralenic Acid,Arthrodont,Glyciram,Glycyram,Jintan,Po 12,12, Po,Acid, Glycyrrhetic,Acid, Glycyrrhetinic,Acid, Rhetinic,Acid, Uralenic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
January 1990, The Journal of international medical research,
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
January 1979, Scandinavian journal of gastroenterology. Supplement,
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
January 1979, Scandinavian journal of gastroenterology. Supplement,
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
January 1982, Scandinavian journal of gastroenterology. Supplement,
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
January 1982, Digestion,
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
January 1979, Scandinavian journal of gastroenterology. Supplement,
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
January 1983, International journal of tissue reactions,
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
December 1988, Lancet (London, England),
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
January 1982, Scandinavian journal of gastroenterology. Supplement,
L Barbara, and E Belsasso, and A Blasi, and E Caenazzo, and G Di Febo, and F Di Mario, and M Giorgi-Conciato, and F Marletta, and M Miglioli, and M Petrillo, and M Salvagnini, and G Scalabrin
July 1979, The Medical journal of Australia,
Copied contents to your clipboard!