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The effectiveness and safety of pirenzepine (PRZ) at 150 mg daily in the treatment of active duodenal ulcer was studied in an open pilot clinical trial followed by a double-blind trial against placebo. The open pilot study showed that pirenzepine was well tolerated and promoted ulcer healing in the 45% of patients within 2 weeks of treatment and in 90% within 4 weeks. The double-blind trial against placebo (PL) Confirmed these results: 60% of the patients in PRZ group and 10% of the patients in PL group showed endoscopic ulcer healing after 2 weeks. This difference was significant. Ninety per cent of the PRZ patients and 50% of the PL patients were completely healed after 4 weeks. In the PRZ group, gastric secretory tests showed a significant decrease in B.A.O. (69%), M.A.O. (33%) and P.A.O. (34%) after 2 weeks. In the PL group, the same parameters had only a small decrease, without statistical significance. There were no pathological changes in laboratory findings in either the open or the double-blind studies. Mild and transient side-effects were observed in 7 of 30 patinets receiving pirenzepine (diplopia and dryness of the mouth).
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
January 1988,
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten,
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
January 1982,
Scandinavian journal of gastroenterology. Supplement,
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
February 1984,
Gut,
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
January 1982,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
August 1986,
East African medical journal,
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
January 1987,
Materia medica Polona. Polish journal of medicine and pharmacy,
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
July 1983,
Zhonghua nei ke za zhi,
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
November 1984,
Lancet (London, England),
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
January 1986,
Minerva dietologica e gastroenterologica,
N D'Imperio, and
G Giuliani Piccari, and
A M Lepore, and
F Sarti, and
P R Dal Monte
January 1982,
Scandinavian journal of gastroenterology. Supplement,
