-transparent.png){kind=logo}
To assess the contribution of sympathetic outflow to blood pressure in patients with essential hypertension, we measured blood pressure and plasma norepinephrine responses to clonidine, an antihypertensive agent that decreases central sympathetic outflow, in 44 patients and in 41 normotensive control subjects of similar age. Among the hypertensive patients, the resting level of plasma norepinephrine was significantly related to the decrease in mean arterial pressure 3 hours after a single oral dose of clonidine 300 micrograms (r = 0.62, p less than 0.001). The magnitude of the depressor response in the patients also was correlated significantly with the decrease in plasma norepinephrine after clonidine (r = 0.60, p less than 0.001). These results suggest that increased sympathetic outflow plays a pathophysiologic role in some patients with essential hypertension.
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
May 1991,
Clinical and experimental pharmacology & physiology,
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
January 1986,
Archivos del Instituto de Cardiologia de Mexico,
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
January 1979,
Hypertension (Dallas, Tex. : 1979),
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
December 1981,
Clinical pharmacology and therapeutics,
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
November 1984,
Clinical pharmacology and therapeutics,
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
June 2019,
BMJ case reports,
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
March 1985,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
October 1984,
Klinische Wochenschrift,
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
April 1987,
Comprehensive therapy,
D S Goldstein, and
P D Levinson, and
R Zimlichman, and
A Pitterman, and
R Stull, and
H R Keiser
November 2015,
Journal of hypertension,
