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Stimulation of alpha 2-adrenergic receptors on enterocytes promotes fluid and electrolyte absorption and inhibits anion secretion. Loss of adrenergic innervation may play a role in impaired intestinal fluid and electrolyte absorption in diabetic patients with autonomic neuropathy. Clonidine, an alpha 2-adrenergic agonist, was used to treat three patients with "idiopathic" diabetic diarrhea after other treatments had failed: The volume of diarrhea declined significantly (p less than 0.01). Diarrhea recurred when the drug was withdrawn, but the patient's condition improved again when clonidine treatment was reintroduced. Hypotension did not occur as a side effect presumably because of the autonomic neuropathy of these patients.
R N Fedorak, and
M Field, and
E B Chang
September 1987,
The American journal of medicine,
R N Fedorak, and
M Field, and
E B Chang
July 1988,
Annals of internal medicine,
R N Fedorak, and
M Field, and
E B Chang
July 1986,
Annals of internal medicine,
R N Fedorak, and
M Field, and
E B Chang
December 1987,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
R N Fedorak, and
M Field, and
E B Chang
April 1995,
Alimentary pharmacology & therapeutics,
R N Fedorak, and
M Field, and
E B Chang
December 1978,
La Clinica terapeutica,
R N Fedorak, and
M Field, and
E B Chang
April 1995,
The American journal of gastroenterology,
R N Fedorak, and
M Field, and
E B Chang
April 1996,
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi,
R N Fedorak, and
M Field, and
E B Chang
December 1999,
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan,
R N Fedorak, and
M Field, and
E B Chang
August 1991,
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS,
