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The changes in the activity of the pentose phosphate cycle produced by the activation or inhibition of different NADPH-consuming pathways have been studied. The inhibition of fatty acid synthesis by kynurenate produced to the same extent, inhibition of the pentose phosphate cycle activity and an increase (about twofold) in the NADPH/NADP ratio. The addition of ter-butyl-hydroperoxide or paraquat, which is metabolized via NADPH-consuming pathways, produced the activation of the pentose phosphate cycle and a decrease in the NADPH/NADP ratio (about threefold). The plot of the NADPH/NADP ratio versus the pentose phosphate cycle activity gave a straight line with a regression index of 0.999. The regulation of the pentose phosphate cycle mainly by the intracellular NADPH/NADP ratio is discussed.
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
July 1987,
Biochemical and biophysical research communications,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
January 1976,
Biochemical and biophysical research communications,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
November 1986,
The Biochemical journal,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
May 1987,
Biochemistry international,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
January 1974,
Advances in enzyme regulation,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
March 1987,
Molecular and cellular biochemistry,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
January 1985,
Voprosy meditsinskoi khimii,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
January 1983,
Molecular and cellular biochemistry,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
January 1982,
Revista espanola de fisiologia,
I Fabregat, and
J Vitorica, and
J Satrustegui, and
A Machado
January 1977,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
