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The effects of various weak, non-, and co-carcinogenic chemicals on 2-acetylaminofluorene-induced mutation in Salmonella typhimurium were studied. We found that a single co-mutagen could provide for either enhanced or decreased mutagenesis. A differential effect on mutagenic expression was dependent upon: (1) the type of inducer of S-9 (supernatant from liver homogenate centrifuged at 9000 x g) liver enzymes; (2) the amount of S-9 enzyme preparation employed; and (3) the combined dose of mutagen plus co-mutagen studied. No effect was observed in the absence of S-9. Our data suggest that in S. typhimurium a primary factor in the alteration of mutagenesis by a combination of chemicals is changes in metabolism of the principal mutagen.
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
January 1983,
Environmental mutagenesis,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
March 1985,
Mutation research,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
June 2007,
The Journal of infection,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
May 1962,
Cancer research,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
March 1978,
Cancer research,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
January 1973,
Voprosy onkologii,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
August 1980,
Chemico-biological interactions,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
July 1979,
Cancer letters,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
September 1982,
Proceedings of the National Academy of Sciences of the United States of America,
C E Weeks, and
T K Rao, and
J A Young, and
T J Slaga, and
J L Epler
January 1946,
British medical bulletin,
