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Twenty-eight patients with squamous carcinomas of the base tongue were seen and evaluated in a conjoint Head and Neck Tumor Board at Stanford between 1976 and 1982. Fourteen patients were treated by combined external beam and interstitial irradiation, 11 of whom had Stage III and IV carcinomas (American Joint Committee). An initial dose of 5000 to 5500 rad was first delivered by external beam irradiation in 5 to 5.5 weeks, followed approximately 3 weeks later by an iridium 192 (192Ir) interstitial implant boost by the trocar and loop technique. The key to successful treatment of these neoplasms was found to be the use of a lateral percutaneous cervical technique, which placed horizontal loops through the oropharyngeal wall above and below the hyoid bone; the superior loop included the pharyngoepiglottic fold and the tonsilloglossal groove. Standard multiple loop implants (submentally inserted) of the base tongue from the vallecula anteriorly to the circumvallate papillae were also used routinely. This approach has been successful, since 10 of the 14 patients (71%) remain without evidence of disease (mean follow-up, 32 months). There have been only two local recurrences, both on the pharyngoepiglottic fold in patients who did not receive the now standard pharyngoepiglottic fold/lateral pharyngeal wall implants. No patients have relapsed after 18 months. The other 14 patients were treated prospectively during the same period by combining initial resection, radical neck dissection, and postoperative irradiation. In this group, there were more locoregional failures compared to the group treated with radiation therapy alone (5 tongue recurrences and 7 neck relapses); in addition, more severe complications were noted in these 14 patients who received surgery and postoperative irradiation. The authors believe that combined external beam and interstitial irradiation is effective treatment for base tongue carcinomas, especially when the high-dose distribution includes the adjacent tonsilloglossal groove, pharyngoepiglottic fold, and oropharyngeal wall to and below the level of the hyoid bone, in addition to treating an adequate base tongue volume.
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
June 1990,
International journal of radiation oncology, biology, physics,
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
January 1974,
Nowotwory,
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
January 1977,
Radiobiologia, radiotherapia,
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
January 1992,
International journal of radiation oncology, biology, physics,
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
January 1978,
Acta radiologica: oncology, radiation, physics, biology,
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
March 1985,
International journal of radiation oncology, biology, physics,
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
February 1955,
Wiener klinische Wochenschrift,
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
January 2002,
American journal of otolaryngology,
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
December 2004,
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al],
D R Goffinet, and
W E Fee, and
J Wells, and
M Austin-Seymour, and
D Clarke, and
J M Mariscal, and
R L Goode
November 2003,
Muscle & nerve,
