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Fourteen mouse monoclonal antibodies (mAbs) to syngeneic and allogeneic thyroglobulins (Tgs) were prepared to study antigenic determinants, their variation among mouse Tgs, and cross-reactivity with various species Tgs. The binding pattern to the Tg panel classified mAbs into three groups but the clustering by competitive-binding inhibition with unlabeled mAbs suggested that at least five antigenic regions existed on the Tg molecule. Mouse Tgs showed no antigenic variation to our mAbs. The cross-reaction with other species Tgs was strictly limited to rat Tgs, excluding one mAb (8.1.1) which reacted with rat and human Tgs. The competitive-binding inhibition by various doses of Tgs substantiated the binding pattern to the Tg panel and furthermore demonstrated that both complete and partial cross-reactions existed.
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