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The effect of cold on vagal action at the heart was studied in sheep, dogs and an isolated guinea pig atrial preparation. During cardiac output measurements in unanaesthetized sheep, by the thermodilution method, bradycardia was evoked on injection of cold indicator in eight of 12 sheep studied. This bradycardia was consistently evoked when blood pressure was increased, but not at normal blood pressure levels. In the guinea pig atrial preparation, which has one vagus nerve attached, bradycardia was evoked by electrical stimulation of the vagus nerve. When the preparation was cooled this bradycardia was potentiated. In anaesthetized dogs, the cut peripheral end of one vagus was stimulated electrically at different frequencies. The linear relationship between pulse interval and vagal frequency was then compared at deep body temperatures of 35, 37, 39 and 41 degrees C. This comparison showed that the vagus prolonged pulse interval more effectively when the animal was cool (35 degrees C) than when it was warm (41 degrees C).
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
January 1985,
Journal de pharmacologie,
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
July 1990,
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons,
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
March 1962,
Bollettino della Societa italiana di biologia sperimentale,
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
May 1992,
Neuroscience letters,
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
September 1993,
Pulmonary pharmacology,
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
September 1986,
Journal of applied physiology (Bethesda, Md. : 1985),
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
June 1998,
Clinical and experimental pharmacology & physiology,
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
February 1980,
Lancet (London, England),
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
May 1986,
Journal of the autonomic nervous system,
E K Potter, and
P Parker, and
A C Caine, and
E R Lumbers
June 2006,
Clinical autonomic research : official journal of the Clinical Autonomic Research Society,
