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The present study was undertaken to determine whether infusion of cholecystokinin (CCK) to plasma concentrations comparable to those found after a meal stimulates pancreatic enzyme secretion and gallbladder contraction. Plasma CCK concentrations were measured by radioimmunoassay using antibody T204, which binds to all carboxyl-terminal CCK-peptides containing the sulfated tyrosine region. Ingestion of a standardized test meal in 7 normal subjects induced significant increases in plasma CCK from 2.0 +/- 0.2 pmol/l to levels between 4.6 +/- 0.6 and 7.3 +/- 1.0 pmol/l (p less than 0.05-p less than 0.0005). Infusion of 2.5 pmol/kg X h CCK 33 resulted in significant increases in plasma CCK from 2.0 +/- 0.2 to 3.9 +/- 0.3 pmol/l (p less than 0.0005). This infusion of CCK induced significant increases in trypsin secretion from 0.5 +/- 0.1 to 1.4 +/- 0.2 KU/15 min (p less than 0.005) and in bilirubin output from 1.6 +/- 0.7 to 30.3 +/- 8.0 mumol/15 min (p less than 0.05). It is concluded that physiological plasma concentrations of CCK stimulate pancreatic enzyme secretion and gallbladder contraction in man.
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
October 1980,
The Journal of laboratory and clinical medicine,
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
January 1987,
Digestive diseases and sciences,
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
August 1988,
Irish journal of medical science,
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
May 1975,
Deutsche medizinische Wochenschrift (1946),
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
December 1992,
European journal of clinical investigation,
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
February 1984,
European journal of clinical investigation,
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
January 1976,
Zeitschrift fur Gastroenterologie. Verhandlungsband,
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
February 1987,
Zeitschrift fur Gastroenterologie,
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
September 1976,
Gastroenterology,
P J Kerstens, and
C B Lamers, and
J B Jansen, and
A J de Jong, and
M Hessels, and
J C Hafkenscheid
July 1993,
The Journal of clinical investigation,
