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The sequence of alterations in the concentration and composition of different plasma lipoproteins following alcohol intake is not known. We therefore monitored the concentrations of cholesterol, triglycerides, phospholipids, and proteins in the major lipoprotein fractions (VLDL, LDL, HDL2, and HDL3) in ten nonalcoholic healthy male volunteers who were given 5.5 g of alcohol per kilogram of body weight during 21/2 days (a weekend). In addition, lipoprotein lipase activity was measured in post-heparin plasma and in adipose tissue and hepatic lipase activity was measured in post-heparin plasma before and after the experiment. in a separate control experiment, the same subjects received meals and liquids without alcohol. Blood alcohol levels remained below 1.5 g/L. Alcohol caused a progressive increase in the fasting VLDL triglyceride and phospholipid concentrations, both of which were doubled during the experiment (P less than 0.001). In contrast, the VLDL cholesterol levels remained unchanged until the third morning, when there was a slight increase. The LDL triglyceride and phospholipid concentrations also rose without simultaneous changes in the LDL cholesterol concentration. Consistent with these changes, the HDL cholesterol concentration showed no response to alcohol during the experiment, but the HDL phospholipid level rose from 76 to 99 mg/dL (P less than 0.001). This was reflected as an increase in the HDL2 concentration from 124 to 158 mg/dL (P less than 0.01), whereas no change occurred in the HDL3 level. The increment of HDL2 concentration was due to a rise of its triglycerides, phospholipids, and apoproteins A-I and A-II but not to a rise of cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
January 1986,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
September 1974,
The New England journal of medicine,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
February 1988,
The Journal of clinical endocrinology and metabolism,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
June 1986,
Polskie Archiwum Medycyny Wewnetrznej,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
September 1983,
The Journal of clinical endocrinology and metabolism,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
October 1979,
European journal of clinical investigation,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
August 1985,
International journal of clinical pharmacology, therapy, and toxicology,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
May 1980,
Journees annuelles de diabetologie de l'Hotel-Dieu,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
January 1989,
Nutrition reviews,
M R Taskinen, and
M Välimäki, and
E A Nikkilä, and
T Kuusi, and
R Ylikahri
January 1984,
Alcoholism, clinical and experimental research,
