Biomaterial Database

Replacement therapy for congenital Factor X deficiency. 1985

R D Knight, and C F Barr, and B M Alving

We studied a young woman with severe (less than 1%) congenital factor X deficiency during a 2-year period in order to document the levels of factor X required to provide hemostasis for vaginal bleeding, epistaxis, and hemarthroses, as well as during surgery. Factor X levels of 9 to 17 percent, achieved with fresh-frozen plasma (FFP) were satisfactory for minor bleeding. Hemostasis was achieved during emergency surgery for hemoperitoneum by increasing the factor X level to 35 percent with a Factor IX concentrate, followed with infusions of FFP to maintain levels between 10 and 20 percent for 6 days postoperatively. These data suggest that factor X levels of 10 to 20 percent are sufficient for hemostasis in factor X-deficient patients even in the immediate postoperative period.

UI	MeSH Term	Description	Entries
D007020	Hypoprothrombinemias	Absence or reduced levels of PROTHROMBIN in the blood.	Factor II Deficiency,Prothrombin Deficiency,Deficiency, Factor II,Hypoprothrombinemia,Deficiencies, Factor II,Deficiencies, Prothrombin,Deficiency, Prothrombin,Factor II Deficiencies,Prothrombin Deficiencies
D008595	Menorrhagia	Excessive uterine bleeding during MENSTRUATION.	Hypermenorrhea,Heavy Menstrual Bleeding,Heavy Periods,Heavy Period,Menstrual Bleeding, Heavy
D010949	Plasma	The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.	Blood Plasma,Fresh Frozen Plasma,Blood Plasmas,Fresh Frozen Plasmas,Frozen Plasma, Fresh,Frozen Plasmas, Fresh,Plasma, Blood,Plasma, Fresh Frozen,Plasmas,Plasmas, Blood,Plasmas, Fresh Frozen
D001803	Blood Transfusion	The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)	Blood Transfusions,Transfusion, Blood,Transfusions, Blood
D004844	Epistaxis	Bleeding from the nose.	Nose Bleed,Nosebleed,Nasal Bleeding,Nosebleeds,Bleeding, Nasal,Bleedings, Nasal,Nasal Bleedings,Nose Bleeds
D005171	Factor X Deficiency	Blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.	Deficiency, Factor 10,Deficiency, Factor Ten,Deficiency, Factor X,Deficiency, Stuart-Prower,Deficiency, Stuart-Prower Factor,Factor 10 Deficiency,Factor Ten Deficiency,Stuart-Prower Deficiency,Stuart-Prower Factor Deficiency,Deficiencies, Factor 10,Deficiencies, Factor Ten,Deficiencies, Factor X,Deficiency, Stuart Prower,Deficiency, Stuart Prower Factor,Factor 10 Deficiencies,Factor Ten Deficiencies,Factor X Deficiencies,Stuart Prower Deficiency,Stuart Prower Factor Deficiency,Ten Deficiencies, Factor
D005260	Female		Females
D006395	Hemarthrosis	Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.	Hemarthroses
D006465	Hemoperitoneum	Accumulations of blood in the PERITONEAL CAVITY due to internal HEMORRHAGE.	Hemoperitoneums
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man