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We investigated splenic reticuloendothelial activity after splenic preservation procedures to determine their effect upon the phagocytic function of the spleen. We performed the following procedures in Sprague-Dawley rats: sham laparotomy, total splenectomy, hemisplenectomy, subtotal splenectomy, or total splenectomy with intraperitoneal splenic autotransplantation. At nine weeks after operation, phagocytic function of the spleen was determined by measuring radiocolloid uptake. Mean (+/- SEM) splenic phagocytic indices for sham laparotomy (41.2 +/- 2.9), hemisplenectomy (44 +/- 2.9), and subtotal splenectomy (43.2 +/- 5.2) were similar; however, the phagocytic index was reduced markedly after autotransplantation (15.8 +/- 2.2). These data demonstrate that the phagocytic function of the spleen after hemisplenectomy and subtotal splenectomy correlates highly with the weight of the splenic remnant; however, phagocytic function after autotransplantation remains reduced even after accounting for differences in splenic weight.
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
June 1991,
South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
May 1994,
The British journal of surgery,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
October 1986,
World journal of surgery,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
December 1987,
The New England journal of medicine,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
March 1985,
Klinicheskaia meditsina,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
January 1999,
Khirurgiia,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
August 1989,
Vestnik khirurgii imeni I. I. Grekova,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
October 1989,
Acta chirurgica Scandinavica,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
January 1995,
Vestnik khirurgii imeni I. I. Grekova,
M A Malangoni, and
L G Dawes, and
E A Droege, and
S A Rao, and
B D Collier, and
U A Almagro
February 1986,
Khirurgiia,
